Prohledat tento blog

neděle 14. července 2019

High Prevalence of PD-L1 Expression in Non-Small-cell Lung Cancer

High Prevalence of PD-L1 Expression in Non-Small-cell Lung Cancer:



.....For the EXPRESS study, online June 12 in Lung Cancer, Dr. Dietel and colleagues examined tumor-sample data on 2,368 patients with stage IIIB/IV NSCLC. They assessed the prevalence of PD-L1 as the percentage of viable tumor cells showing partial or complete membrane staining (tumor proportion score, or TPS).
Overall, 48% of samples had PD-L1 TPS <1%, 52% had PD-L1 TPS of at least 1%, and 22% had PD-L1 TPS of at least 50%. The prevalence was similar across regions.
Tumor samples with PD-L1 TPS of at least 50% were less common among patients with sensitizing EGFR mutations and those with ALK translocations. 
No other demographic or clinical characteristics appeared to be associated with differences in the prevalence of PD-L1 expression.
"Overall," the researchers conclude, "these results indicate that 52% of patients with advanced NSCLC express PD-L1 on tumor cells 

....více https://bit.ly/2Nm6rzc


Žádné komentáře:

Okomentovat

The first case of micropapillary adenocarcinoma associated with cystic airspace in a non‐smoking man

The first case of micropapillary adenocarcinoma associated with cystic airspace in a non‐smoking man Saeko Takahashi   Saori Murata   Re...

Translate